1.9.2008 | 15:30
Fyrirlestur nóbelsveršlaunahafans Susumu Tonegawa
Ég skelli hér inn tilkynningu um fyrirlestur Susumu Tonegawa, sem eftir minni bestu vitund er öllum opinn:
Fyrirlestur nóbelsveršlaunahafans Susumu Tonegawa veršur haldinn laugardaginn 6. september kl. 14.00-15.00 ķ hśsakynnum Hįskólans ķ Reykjavķk, Ofanleiti 2, stofu 101. Fyrirlesturinn er ķ boši Tękni- og verkfręšideildar Hįskólans ķ Reykjavķk ķ samstarfi viš Taugavķsindafélag Ķslands.
Yfirskrift fyrirlestursins er "Molecular, cellular, and circuit mechanisms for hippocampal learning and memory" og śtdrįtt śr honum mį sjį hér aš nešan.
Abstract
We study molecular, cellular, and neuronal circuit mechanisms underlying acquisition, consolidation and retrieval of hippocampus-dependent memory in rodents. Our primary approach is to generate cell type and adult-restricted knockout mice and characterize them using multifaceted methods including molecular and cellular biology, in vitro and in vivo electrophysiology, confocal and two photon microscopy and behavioral tasks. The data obtained to date indicate that NMDA receptor-mediated synaptic plasticity in area CA1 plays a pivotal role in special and other hippocampus dependent learning and memory. The same receptors and synaptic plasticity in area CA3 are dispensable for the acquisition of reference memory, but play an important role in "pattern completion"-the ability to recall an entire experience with limited recall cues as well as in one trial-based rapid learning. NMDA receptor function in dentate gyrus (DG) is also dispensable for reference memory, but is important in "pattern separation," the ability to form distinct memories of similar events. These studies attest the power of this multi-faceted genetic, physiological and behavioral approach in understanding mechanisms underlying cognition.
Susumu Tonegawa er meš doktorspróf ķ sameindalķffręši frį hįskólanum ķ Kalifornķu ķ San Diego. Hann var nżdoktor viš Salk Institute en gekk sķšan til lišs viš Ónęmisfręšistofnunina ķ Basel (Basel Institute for Immunology). Įriš 1981 varš hann prófessor ķ lķffręši viš MIT og hóf rannsóknir viš Rannsóknarstofnun ķ krabbameinsfręšum (Center for Cancer Research). Hann stofnaši Center for Learning and Memory viš MIT įriš 1994.
Dr. Tonegawa hefur hlotiš fjölmargar višurkenningar fyrir rannsóknir sķnar, žar į mešal fékk hann Nóbelsveršlaunin ķ lķfešlisfręši eša lęknavķsindum įriš 1987.
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